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Moha Kdci

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  3. 🚨I announce to you that the first historical study on hppd brains will be done🚨🇲🇫

    in MAIN AND GENERAL FORUM

    Posted · Edited by Moha Kdci

    On 6/5/2023 at 9:25 AM, Jay1 said:

    Très intéressant à entendre, merci pour la publication. 

    Contactez-moi si je peux vous être utile.

    We have my Professor, his relationships like Pr Denis Le Bihan (He is the greatest neuroscientist in the world), we (Paris 🇲🇫🇪🇺) have the best technological equipment in the world, there will be the team from the center of research (composed of specialists in neuro-imaging), the support of the government... everything is in the process of being constituted!

     

    But thank you Jay, yes gladly if you have any questions. there is information that I should keep confidential

     

    the wikipedia page of Professor Denis le bihan and friend of my Professor

    Denis Le Bihan (born July 30, 1957) is a medical doctor, physicist, member of the Institut de France (French Academy of sciences),[1] member of the French Academy of Technologies and director since 2007 of NeuroSpin, an institution of the Atomic Energy and Alternative Energy Commission (CEA) in Saclay, dedicated to the study of the brain by magnetic resonance imaging (MRI) with a very high magnetic field. Denis Le Bihan has received international recognition for his outstanding work, introducing new imaging methods, particularly for the study of the human brain, as evidenced by the many international awards he has received, such as the Gold Medal of the International Society of Magnetic Resonance in Medicine (2001),[2] the coveted Lounsbery Prize (US National Academy of Sciences and French Academy of sciences 2002), the Louis D. Prize from the Institut de France[3] (with Stanislas Dehaene, 2003), the prestigious Honda Prize (2012),[4] the Louis-Jeantet Prize (2014), the Rhein Foundation Award (with Peter Basser) (2021). His work has focused on the introduction, development and application of highly innovative methods, notably diffusion MRI.

    Denis Le Bihan studied medicine and physics in Paris. After an internship in neurosurgery, radiology and nuclear medicine, he obtained his doctorate in medicine in 1984 (University of Paris VI) with the specialty "radiology". He also follows a course in human biology (functional explorations of the nervous system, mathematical models in medicine). His training in physics focuses on nuclear physics and elementary particles. He obtained his doctorate in physics in 1987, his thesis focusing on a completely new method of magnetic resonance imaging that he introduced and developed (diffusion imaging and IVIM imaging (en) for IntraVoxel Incoherent Motion). In 1987, he joined the National Institutes of Health (NIH) in Bethesda, Maryland, USA, where he remained until 1994. This is where he continues to develop diffusion MRI, introducing diffusion tensor MRI (DTI) with Peter Basser. Denis Le Bihan joined the Frédéric Joliot Hospital Service of the CEA in 1994 to head the anatomical and functional neuroimaging laboratory. In 2000, he became Director of the Federal Institute for Research in Functional Neuroimaging (IFR 49). He presided over the founding and opening of NeuroSpin in 2007 and has been its director since then. Since 2005, Denis Le Bihan has also been a regular guest professor at Kyoto University (Human Brain Research Center).

    NeuroSpin has been able to mobilize significant public funding to conduct innovative research in neurodegenerative disease imaging. As part of the Franco-German Iseult NeuroSpin project, CEA teams are in the process of finalizing the construction of a unique MRI scanner using a record magnetic field of 11.7 teslas, thanks to a magnet of more than 100 tons with an original design.[6

     

    Denis Le Bihan is particularly recognized for his pioneering work on diffusion MRI, a concept whose principles he established[7] and demonstrated its potential,10.1148/radiology.161.2.3763909<[8] particularly in the medical field during the 1980s. Since then, Denis Le Bihan has continued to develop and perfect the method, and has further extended its fields of application. Diffusion MRI is used worldwide to study the anatomy of our brain, its connections and functioning. In medicine, major neurological applications include acute stroke and white matter disorders, including psychiatric disorders.[9] Diffusion MRI is also of great importance outside the brain for the detection and monitoring of cancers and metastases.[10]

    Diffusion MRI and Stroke

    Diffusion MRI allows us to detect in the context of the emergency, a few hours after the onset of a stroke, the area of the brain that is dying because it is deprived of blood flow when a blood vessel has been obliterated by a clot. The consequences of stroke are formidable: it is the third leading cause of death, and in 30% of cases it leaves severe functional sequelae (hemiplegia, speech disorders) in patients who become unable to support themselves. Stroke is by far the leading source of disability in the long term, with significant social and economic consequences. Diffusion MRI has led to the urgent and accurate identification of stroke[11] and the development of drugs that, injected in the very first hours following stroke, can dissolve the clot and immediately clear up symptoms. The vast majority of MRI scanners manufactured and installed worldwide are equipped with the diffusion MRI method introduced by Denis Le Bihan.

    Intracerebral connectivity

    The brain contains about 100 billion neurons, our grey matter, which are connected to each other at a rate of 1,000 to 10,000 connections per neuron through extensions called axons that constitute the fibres of the white matter. The diffusion MRI made it possible, for the first time, to produce 3D images of these connections (tractography), in a way that is totally harmless to patients (just lie down for about ¼ hours in the MRI scanner). The principle is based on the fact that the diffusion of water is slower perpendicular to the fibres. It is therefore sufficient to obtain images of the diffusion of water in different directions to account for the orientation of the fibres, which Denis Le Bihan's team first showed in 1991.[12] With the diffusion tensor MRI technique (DTI) developed by Denis Le Bihan and Peter Basser at the NIH in 1992[13][14] and its variants developed since then (high angular resolution methods), it is now possible to obtain atlases of intracerebral connections with very high accuracy.[15] Diffusion MRI can therefore not only diagnose and study white matter fibre disorders (such as multiple sclerosis), but also subtle connection abnormalities in neural circuits. These abnormalities that appear very early in life may reflect some functional disorders (dyslexia) or psychiatric conditions (schizophrenia, autism). At the other end of life, normal or pathological aging (neurodegenerative diseases, such as Alzheimer's disease) is also accompanied by a rearrangement of brain connections that diffusion MRI shows.[16]

    International recognition

     

    As a pioneer in his field, Denis Le Bihan has received many awards and recognitions during his career.

    • 2022: Antoine Béclère Medal
    • 2021: Technology Award of the Eduard Rhein Foundation[20]
    • 2014: Louis-Jeantet Prize for Medicine
    • 2012: Honda Prize
    • 2011: European Congress of Radiology, Opening Lecturer
    • 2010: Holst Award, University of Eindhoven/Philips Research
    •  2010: JA Vezina Award, Elected Honorary Member of the Canadian Society of French-speaking Radiology
    •  2009: Béclère Honorary Lecturer, Medal for the 100th anniversary of the French Society of Radiology
    •  2009: Fellow of the European Society for Magnetic Resonance in Medicine and Biology
    •  2004: Elected Honorary Member of the American Society of Neuroradiology
    •  2003: Louis D. Foundation Prize, Institut de France
    •  2002: Lounsbery Prize, US National Academy of Sciences and French Academy of sciences
    •  2002: Elected member of the European Academy of Sciences
    •  2001: Gold Medal, International Society of Magnetic Resonance in Medicine
    •  2000: Fellow, International Society of Magnetic Resonance in Medicine
    •  1995: Kodak-Landucci Prize, Laureate of the French Academy of sciences, Paris
    •  1994, 1993, 1992, 1990: Editor's Recognition Award, with Distinction for Outstanding Review in Radiology
    •  1994: Award of the European Society of Magnetic Resonance in Medicine and Biology
    •  1993: Cum Laude Award, American Society of Neuroradiology
    •  1993: Magna Cum Laude, Society of Magnetic Resonance Imaging
    •  1991: Sylvia Sorkin Greenfield Award (best publication in Medical Physics, American Association of Physicists in Medicine (AAPM))
    •  1991: Cum Laude Citation, Society of Magnetic Resonance Imaging
    •  1989: Foucault Prize, French Physics Society
    •  1989: Magna Cum Laude Award, Radiological Society of North America
    •  1987: Magnetic Resonance Evaluation College Award
    •  1986: René Djindjian Prize, French Society of Neuroradiology
    •  1986: Cum Laude Award, Radiological Society of North America
    •  1985: Michel Katz Prize, French Society of Radiology
    • Upvote 1

  7. 🚨I announce to you that the first historical study on hppd brains will be done🚨🇲🇫

    in MAIN AND GENERAL FORUM

    Posted · Edited by Moha Kdci

    🚨 Hello everyone, it's been a long time since i've logged in, i was focused on organizing the world's first hppd brain study

    I have finished my meeting with the French Professor, head of the unit of the most famous hospital in Paris.

     

    He was sensitive to your suffering, and he decided to do the first research in the world on hppd brains, he has relations and links with great French and European neuroscientists.

     

    The Paris research center is the most high-tech research center in the world (Magnetoencephalography, Fmri 7 Teslas, Diffusion-weighted magnetic resonance imaging, they received the most powerful MRI in the world 11.7 Teslas)

     

    for the common good, the French professor wanted to integrate people from all over the world and expand the recruitment with Americans, Europeans, Australians and other people from all over the world.

     

    As I told a McConnell board member,

    The Professor requested and sent an email to Pr McConnell asking him to organize the research together, to merge and collaborate. Unfortunately for the Hppders of the world Professor McConnell did not answer and the study will be reserved for the French.

     

    As you know, my family is linked to the French government.

     

    This morning, we therefore decided that we were going to write a letter to the French Minister of Health (my cousin knows him) and ask him to have access to the research center in Paris to carry out the study.

     

    I am proud to announce that the first Hppd neuroimaging study will be done (Magnetoencephalography, Fmri 7 Teslas, Diffusion-weighted magnetic resonance imaging)

    • Like 4

  13. MRIs that will detect the area of the damaged hppd brain

    in MAIN AND GENERAL FORUM

    Posted

    6 hours ago, Spartan said:

    C'est génial et fascinant..

    Je sais que le FMRI sera inclus dans l'étude HPPD de l'université Maquarie / Protocole

    J'ai initié ce processus il y a environ 8 ans lors de ma rencontre avec les meilleurs psychiatres de Nero en Australie.

    Protocole du trouble persistant de la perception des hallucinogènes (HPPD): neuroimagerie multimodale pour découvrir la pathogenèse neurobiologique - Université Macquarie (mq.edu.au

    J'adorerais partager plus sur l'étude et le protocole, même si c'est confidentiel.

    Je soupçonne qu'une hypothèse pour l'étiologie est que... une partie du cerveau affectée est le lobe occipital, ou une activité épileptique se déroulant dans le lobe occipital. 

    Ce serait formidable / Je suggérerai aux médecins et aux professeurs d'inclure également le SPECT.

    Très cool, merci pour le partage ! 

     

     

    Too bad you don’t share information about the fmri protocol. Some people may have access to it in their country, they could do the same protocol and it will reveal the hppd mystery

  14. MRIs that will detect the area of the damaged hppd brain

    in MAIN AND GENERAL FORUM

    Posted

    I’m going to list the most powerful MRIs that will detect the area of the damaged brain 

    Single-photon emission computed tomography (SPECT, or less commonly, SPET) is a nuclear medicine tomographic imaging technique using gamma rays
    Https://youtube.com/watch?v=b3Dtrt5pJ7U&feature=share

    Second imaging : Functional magnetic resonance imaging or functional MRI (fMRI) measures brain activity by detecting changes associated with blood flow.
    https://onlinelibrary.wiley.com/doi/full/10.1002/acn3.50986

    Third imaging : 11.7 teslas: The World-Record Magnetic Field Generated by a Human MRI Magnet
    https://www.cea.fr/english/Pages/News/premieres-images-irm-iseult-2021.aspx

    Fourth imaging : Magnetoencephalography (MEG) is the newest, most advanced method of recording and evaluating the brain while it is actively functioning. This recording provides a direct measurement of the ongoing function of normal neurons and can pinpoint the location of malfunctioning neurons.

    That’s the goal friends, if we pass these machines. The damage in Our Hppd brain will be revealed

    Tell me what you think !

    • Like 1
    • Upvote 1

  15. New MRI Techniques may be the answer to understanding HPPD.

    in MAIN AND GENERAL FORUM

    Posted

    1 hour ago, Fawkinchit said:

    Je voulais commencer un nouveau sujet pour tenter de trouver des participants volontaires pour une nouvelle stratégie dans les techniques d'IRM que j'ai trouvées. Je n'ai pas eu le temps d'examiner toutes les informations aussi minutieusement que je le souhaiterais, cependant, ce que j'ai trouvé semble très prometteur.

    En bref, il semble qu'une de mes vieilles théories sur l'IRM et ses lacunes pour détecter une légère perte neuronale diffuse était exacte, et que de nouvelles techniques sont utilisées pour surmonter ces lacunes. Dans les deux articles que je publierai, il devrait être évident pour tout le monde que ces techniques sont beaucoup plus précises pour accéder à la perte neuronale et à la densité neuronale. Ces types d'IRM sont appelés IRM T1p et IRM R2t, pas de RTD2 lol.

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2637389/

    https://medicine.wustl.edu/news/background-signal-in-mri-scans-reveals-how-brain-cells-develop-and-die/

    Il suffit de lire les articles et je pense que tout le monde verra par lui-même pourquoi rien n'est trouvé dans nos IRM, c'est spécifiquement dû au fait que les IRM ne sont pas des techniques efficaces pour accéder à une perte neuronale diffuse légère, mais plutôt efficaces pour détecter les neurones bruts. perte.

    Si quelqu'un était prêt à faire l'un de ces types d'IRM et pouvait trouver un médecin qui sait comment administrer les techniques, je pense que nous pourrions très bien trouver le diagnostic final précis de l'HPPD, et à tout le moins comprendre sa cause, ce qui ouvrirait le champ à un accès plus précis aux options de traitement, et supprimerait également les prescriptions sans éclat et les fausses tentatives de traitement dont nous sommes tous très conscients.

    J'espère vraiment que nous pourrons trouver des personnes prêtes à rechercher cela et à faire des IRM, je crois sincèrement qu'elles nous donneront beaucoup plus d'informations sur la condition qu'une IRM normale générale.

    S'il vous plaît laissez-moi savoir ce que toutes vos pensées sont à ce sujet. Merci beaucoup!

     

     

    Does this Mri exist in Europe and France? I can’t find it on the internet

  18. Brain damage as a cause of HPPD: the loss of specific GABA-releasing inhibitory interneurons

    in MAIN AND GENERAL FORUM

    Posted

    23 hours ago, MentholFlavoring said:

     

    Dans un futur proche, je dirais non. Pour l'instant, nous pouvons traiter nos symptômes avec des anticonvulvants/benzodiazépines ou d'autres composés qui modulent l'activité excitatrice/inhibitrice.  Ce que j'ai vu, c'est que certaines personnes ont du succès avec  la lamotrigine, la clonidine, le clonazépam, et récemment quelqu'un a mentionné le perampanel qui semble assez intéressant.

    Cependant, le domaine de la recherche sur les lésions cérébrales évolue rapidement avec de nombreux médicaments potentiels entrant dans des essais cliniques qui se concentrent spécifiquement sur l'inversion des lésions cérébrales. Bien qu'actuellement, ils soient principalement à l'essai pour des maladies telles que la maladie d'Alzheimer, la maladie de Parkinson, la sclérose en plaques, etc., il est raisonnable d'espérer que, disons d'ici dix ans, nous disposerons de médicaments capables d'améliorer ou même d'inverser les lésions cérébrales. De toute façon, n'ayez pas peur de l'idée qu'une lésion cérébrale est permanente parce qu'elle  ne l'est tout simplement pas . Du moins pas avec les technologies modernes. Chez les souris et les animaux, il a déjà été inversé plusieurs fois.

     

    J'ai trouvé plus d'indices que HPPD est probablement une lésion cérébrale, à partir de la page Wikipedia :

    "La désinhibition chronique peut se produire à partir de la destruction et / ou du dysfonctionnement des interneurones inhibiteurs sérotoninergiques corticaux impliquant le neurotransmetteur inhibiteur, l'acide gamma-aminobutyrique (GABA)". [la source]

    Et la page Wikipédia sur  le trouble de dépersonnalisation-déréalisation suggère également des anomalies qui indiquent une blessure ou une perte neuronale quelconque :

    "Plusieurs études analysant les résultats de l'IRM cérébrale de patients atteints de DPDR ont révélé une diminution de l'épaisseur corticale dans le gyrus temporal moyen droit, une réduction du volume de matière grise dans le caudé droit, le thalamus et le gyri occipital, ainsi qu'une intégrité inférieure de la substance blanche dans les temporaux gauche et droit. régions temporo-pariétales. [la source]

    Si vous souffrez de DP / DR de HPPD, vous pourriez également avoir une sorte de lésion neuronale dans d'autres zones du cerveau (donc pas seulement le cortex visuel), ce qui, malheureusement, comme je viens de le réaliser, semble assez étendu. Peut-être y a-t-il une perte d'interneurones plus inhibiteurs dans tout le cerveau, ce qui indiquerait une lésion plus étendue non seulement concentrée sur une petite partie du cerveau. Je vais essayer de lire un peu plus à ce sujet.

    Hello do you think that deep brain stimulation with the implant that is placed on the brain could attenuate or eliminate the Hppd?

    Deep-Brain-Stimulation-DBS.jpg

  21. Your opinions

    in MAIN AND GENERAL FORUM

    Posted

    "When we stare at a static image for too long, the cells responsible for processing the stimulus from the static image eventually turn “off". The stimulus isn't enough to induce firing of chemical signals any more. So instead, the LGN cells responsible for relaying motion take over to signal according to the stimulus. Thus, we perceive the image to be moving even when it's actually static. Vice versa applies for the optical illusions where staring at a moving ballerina makes you see that she's actually moving in the opposite direction to the first time you saw her, or staring at a moving picture then looking at a static picture makes you see a wobbly picture instead."

  22. I think I found the name of my symptom (illusory motion in a stationary image, Letter moving when I read) = Motion Aftereffect

    in MAIN AND GENERAL FORUM

    Posted

    « the brain is the middle-temporal lobe. This is the area of the brain, in which research indicates is vital to motion perception (Wolfe, et al., 2012,p. 175). The neurons inside the brain are specialized to detect and interpret different directions of motion, meaning that some neurons in the brain are specialized to only “see” and process upward motion, and others are specialized to see downward motion.   The trick is that “when we view a stationary object, the response of neurons turned to different directions are normally balanced”(Wolfe, et al., 2012,p. 175) or they cancel each other out so we see the object as stationary.

        So when we decided we should read our book, the neurons that are specialized to see motions left to right are going to start, but the other ones, the right to left, are going to be slower. Therefore they will throw off the balance and the words will seem to move on the page. »

    May I have your opinion?

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